(Yes, I'm writing this at 1:00 AM. I've had a lot of coffee today.)
I'm getting an awful lot of queries from folks who start off by saying something along the lines of "I'm an avid reader of your blog..." These query writers then go on to demonstrate that they haven't actually read the most important part of my blog: my submission guidelines. And in every other place online where you may find my name listed as literary agent, you'll also find those very same submission guidelines posted, submission guidelines that ask for the first five or six pages of your manuscript cut and pasted into the body of your email query.
I ask for the first few pages of your manuscript for a really good reason: I want to see a sample of your writing. When you send me a query that doesn't include a sample of your writing, you're wasting my time and doing yourself a great disservice.
It doesn't matter which agent you decide to query; you should always take the time to research that agent's submission guidelines first.
We all have a limited amount of time that we can spend on each query letter; make that time count for something when we're reading yours, okay?